UHRFI:a novel metabolic guardian restricting AMPK activity

摘要：

AMP-activated protein kinase (AMPK) serves as a central guardian maintaining energy homeostasis under nutrient stress and/or energy crisis.The study by Xu et al.identified that a nuclear factor UHRF1 (ubiquitin-like with plant home-odomain and RING finger domains 1) suppresses AMPK activity in the nucleus by recruiting PP2A to dephosphorylate AMPK at T172,which in turn governs cytoplasmic AMPK activity in regulation of glucose and lipid metabolism.

所属期刊栏目：32

在线出版日期：2022-03-11（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：3-4