Nuclear translocation of the 4-pass transmembrane protein Tspan8
Dear Editor,
Transmembrane proteins with multiple transmembrane domains are rarely found inside nuclei for good reason.To achieve intranuclear localization,the hypothetical transmembrane protein must first be extracted from its host membrane and the multiple hydrophobic transmembrane domains must be protected from the hydrophilic environment of the cytoplasm to maintain the proper conformation of the protein.Mechanistically,this poses consider-able challenges.
31
We are grateful to Qi Hai's lab in Tsinghua University for the generous gift of B16 cells,and to Lin Xin's Lab in Tsinghua University for 4T1 cells;We thank Yahui Tian and Professor Liang Chen from Jinan University for providing us with HCC827,H1975 and PC9 cells;We thank all members in Wang's group and Yu's group for helpful discussion;This research was supposed by the National Natural Science Foundation of China ;and the National Natural Science Foundation of China
2021-12-16（万方平台首次上网日期，不代表论文的发表时间）
共4页
1218-1221
