Linear ubiquitin chains break blood vessel branches
New work published in Molecular Cell by Fu et al.reveals that the protein kinase ALK1 is deregulated when the enzymes assembling and disassembling Met1-ubiquitination,LUBAC and OTULIN,are inhibited or missing.This latest non-degradative role for ubiquitin impacts on Smad1/5 signaling and deregulates angiogenesis downstream of bone morpho-genetic proteins,adding to the growing list of Met1-polyubiquitin-regulated cellular pathways.
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2021-11-11(万方平台首次上网日期,不代表论文的发表时间)
共2页
1045-1046