Dear Editor,
Yes-associated protein(YAP)is a transcriptional coactivator that plays an essential role in promoting cell proliferation,development and stem cell fate.1 Aberrant YAP activation is prevalent in diverse types of human solid cancers.2 In mammals,a kinase cascade including MST1/2 and LATS1/2 phosphorylates YAP to prevent its nuclear translocation and subsequent interaction with the TEA domain transcription factors TEAD1-4 in the canonical Hippo pathway.Previous studies have intensively emphasized the upstream signals from the Hippo kinase cascade that regulates YAP;1,3 however,the epigenetic regulatory mechanism of YAP transcriptional activity is far less understood.Given the importance of YAP in cancer progression and limited druggability of YAP/TEAD as transcriptional factors,identification of YAP proximal regulators is of great importance to develop new therapeutic strategies for the treatment of cancer.
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We thank Drs;Junying Yuan and Nan Liu for critical reading of the manuscript;We thank J;Hu Lab and Y;Geng for help with live-cell imaging;We thank Z;Zhang Lab for the protein purification platform;We thank National Center for Protein Science Shanghai for the BLI assays;This work was supported by the National Key R&D Program of China;the National Natural Science Foundation of China;the Shanghai Municipal Science and Technology Major Project;and the joint postdoc program with Janssen R&D