Somatic mutation accumulation seen through a single-molecule lens
Somatic mutations(SMs)accumulate over the lifetime of cells and can lead to cancer and other diseases;however,SMs can be difficult to detect,especially when they are present in very few cells.In a recent Nature paper,Abascal et al.develop a protocol capable of detecting SMs present on only a single molecule of DNA and apply it to both mitotic and post-mitotic human tissues.
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2021-10-13(万方平台首次上网日期,不代表论文的发表时间)
共2页
949-950