Heart defects recapitulated in human cardioids
A major obstacle to understanding how and why congenital defects occur in the heart is the absence of models that recapitulate the basic cell lineage architecture of human heart development.In a recent study in Cell,Hofbauer and colleagues present compelling evidence that they have created such a model from human pluripotent stem cells by guiding self-organization within cell aggregates(or organoids)which they refer to as"cardioids";these undergo patterning and morphogenesis to form a cavity-like chamber as in early heart development.
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2021-10-13(万方平台首次上网日期,不代表论文的发表时间)
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947-948