Finding a new job:glutamate signaling acts in atrial cardiomyocytes
Cardiomyocytes(CMs)and neurons possess similar funda-mental functions of excitability and conduction.Xie et al.provide evidence that the glutamatergic transmitter system regulating excitability and conduction in neurons is endo-genously expressed and active in atrial CMs,uncovering new neuron-like signaling properties of atrial CMs.
Cardiac excitability and conduction are fundamental functions of the heart.Regulation of these functions is undeniably complex and involves multiple mechanisms including,but not limited to,autonomic nervous,nitric oxide signaling and redox balance systems.The role of the adrenergic and cholinergic nerves,part of the autonomic nervous system,in controlling cardiac electrical activity is well described and is primarily mediated by the classical neurotransmitters norepinephrine and acetylcholine.However,emerging evidence suggests that another neurotransmitter system,involving glutamate,the most abundant excitatory neurotransmitter in the nervous system,may participate in governing cardiac excitability and conduction.
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2021-10-13（万方平台首次上网日期，不代表论文的发表时间）
共2页
943-944
