Cryo-EM structure of the AVP-vasopressin receptor 2-Gs signaling complex
Dear Editor,
The highly conserved neuropeptides arginine vasopressin(AVP)and oxytocin(OT)signal through a family of Class A G protein-coupled receptors(GPCRs),the AVP receptors V1aR,V1bR and V2R and the OT receptor OXTR.1,2 V2R is predominantly found in the kidney and plays a critical role in body fluid homeostasis.2 Among all AVP and OT receptors,V2R is the only one that activates the heterotrimeric Gs family to induce cAMP accumulation(Supple-mentary information,Fig.S1).
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We thank the Cryo-EM Facility Center of the Chinese University of Hong Kong,Shenzhen for providing technical support during EM image acquisition;is supported by a grant from Science,Technology and Innovation Commission of Shenzhen Municipality;and in part by the Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship at the Chinese University of Hong Kong,Shenzhen;is supported by the grant R35GM128641 from the National Institutes of Health,the United States of America
2021-09-13（万方平台首次上网日期，不代表论文的发表时间）
共3页
932-934
