Molecular basis of ligand recognition and activation of human V2 vasopressin receptor
Dear Editor,
Vasopressin type 2 receptor(V2R)belongs to the vasopressin(VP)/oxytocin(OT)receptor subfamily of G protein-coupled receptors(GPCRs),which comprises at least four closely related receptor subtypes:V1aR,V1bR,V2R,and OTR.1 These receptors are activated by arginine vasopressin(AVP)and OT,two endogenous nine-amino acid neurohypophysial hormones,which are thought to mediate a biologically conserved role in social behavior and sexual reproduc-tion.2 V2R is mainly expressed in the renal collecting duct principal cells and mediates the antidiuretic action of AVP by accelerating water reabsorption,thereby playing a vital role in controlling water homeostasis.
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We thank all staff members of the Cryo-EM Centre,Southern University of Science and Technology for their assistance in data collection.This work was partially supported by the Ministry of Science and Technology;National Natural Science Foundation of China;National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program";Shanghai Municipal Science and Technology Major Project;CAS Strategic Priority Research Program;Start-up funding by Fudan UniversityQ.Z.;Wellcome Trust 209407/Z/17/Z;National Key R&D Program of China;Guangdong Provincial Key Laboratory of Brain Con-nectome and Behavior;CAS Key Laboratory of Brain Connectome and Manipulation
2021-09-13（万方平台首次上网日期，不代表论文的发表时间）
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929-931
