Nascent RNA m6A modification at the heart of the gene-retrotransposon conflict

摘要：

Retrotransposons are highly abundant mobile genetic elements in mammalian genomes and can interfere with many genomic processes,particularly the transcription of genes.A study by Xiong et al.reveals that segments of nascent RNAs containing retrotransposons are enriched in N6-methyladenosine and act as transcriptional roadblocks for elongating RNA polymerase Ⅱ,but that cellular proteins capable of binding to these RNAs,SAFB/SAFB2,can mitigate this effect.

所属期刊栏目：31

资助基金：Work in the laboratory of GC is supported by the French government,through the Agence Nationale de la Recherche;the Fondation pour la Recherche Médicale;InsermGOLD cross-cutting programme on genomic variability;CNRS;and the University Hospital FederationFHUOncoAge

在线出版日期：2021-09-13（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：829-831