Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor

摘要：

Dear Editor,
Infertility poses a major challenge to human reproductive health,affecting approximately 48 million women worldwide.1 Assisted reproductive techniques (ART),including in vitro fertiliza-tion (IVF) and intracytoplasmic sperm injection (ICSI),enable infertile women to have their biological embryos in vitro and further give birth to babies after embryo transfer.However,about 10％ of all human embryos produced by ART are blocked in the early embryonic stage2 and approximately 2％ fertilized oocytes derived from ART could not accomplish the first cell division.

所属期刊栏目：31

资助基金：The authors sincerely thank the patients and their families for their participation;We are grateful to Drs;Yuehong Bian,Yang Zou,Shizhen Su,Ping Yang,Rusong Zhao and Jinzhu Song from Shandong University,China for their enthusiastic technical advice;We also thank Prof;Jinsong Li from State Key Laboratory of Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Science,Prof;Qiang Wang from Nanjing Medical University,Prof;Tianqing Li from Kunming University of Science and Technology and Prof;Wei Xie from Tsinghua University for their valuable suggestions on the study;This research was supported by the National Key R&D Program of China 2018YFC1004000,2017YFC1001504,2017YFC1001600,the Basic Science Center Program 31988101 and the National Natural Science Foundation of China 81871168,31900409,31871509;the Foundation for Distinguished Young Scholars of Shandong Province ;the Innovative Research Team of High-Level Local Universities in Shanghai

在线出版日期：2021-08-04（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：814-817