Ultrasensitive antigen density discrimination by synNotch
In a recent study published in Science,Hernandez-Lopez et al.engineered a low-to-high two-step regulatory circuit that allows T cells to discriminate target antigens with an ultrasensitive threshold.In this circuit,low-affinity synNotch receptor controls the expression of the high-affinity chimeric antigen receptor (CAR);thus,the only time the CAR construct is expressed is in the presence of high levels of antigen,preventing off-tumor CAR T cell recognition.
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2021-08-04(万方平台首次上网日期,不代表论文的发表时间)
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725-726