Structural basis of human α7 nicotinic acetylcholine receptor activation
Dear Editor,
Nicotinic acetylcholine receptors (nAChRs) are a class of pentameric ligand-gated ion channels (pLGICs) widely expressed in nervous system.nAChRs function as neurotransmitter receptors that respond to endogenous acetylcholine and choline,modulat-ing neuronal excitability and synaptic communication.The homomeric α7 nAChR is among the most abundant subtypes of nAChR in the brain.Dysfunction of α7 is found to be associated with several neuropsychiatric and neurologic disorders,including schizophrenia and Alzheimer's disease.1,2 Stimulation of α7 has been reported to improve attention,cognitive performance,and neuronal resistance to injury.
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We thank the Center for Integrative Imaging of University of Science and Technology of China Hefei,and the Center of Cryo-Electron Microscopy of Zhejiang UniversityHangzhou for providing the cryo-EM facility support;This work was funded by the National Natural Science Foundation of China ;the National Key R&D Program of China ;and the Strategic Priority Research Program of Chinese Academy of Sciences
2021-07-12（万方平台首次上网日期，不代表论文的发表时间）
共4页
713-716
