Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters
Dear Editor,
The electroneutral K+-Cl-cotransporters(KCCs)play fundamental roles in trans-epithelial transport,cell volume regulation,and neuronal excitability.1 The neuronal-specific KCC2(SLC12A5)and glial-expressed KCC3(SLC12A6)are essential for normal develop-ment and function of the nervous system.Mutations in KCC2 have been linked with human idiopathic generalized epilepsy2 and schizophrenia.3 KCC3-dependent Cl-transport across the choroid plexus epithelia is involved in the production of cerebrospinal fluid.
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2021-05-31(万方平台首次上网日期,不代表论文的发表时间)
共3页
482-484