Mitochondrial replacement in macaque monkey offspring by first polar body transfer

摘要：

Dear Editor,
Mitochondrial DNA(mtDNA)mutations are maternally inherited to the offspring and mitochondrial replacement therapy(MRT)provides a promising approach for preventing mtDNA-related diseases.1,2 First polar body transfer(PB1T)has been used for mitochondrial replacement to generate mouse offspring and normal human embryos that yield embryonic stem cells.4 However,generation of primate offspring using PB1T has not been reported.Here,we show that PB1T-based mitochondrial replacement could generate healthy macaque monkey(Macaca fascicularis),a useful non-human primate model for evaluating methods that may improve the efficiency and safety of PB1T for MRT.

所属期刊栏目：31

在线出版日期：2021-04-01（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：233-236