Structural insights into the activation of GLP-1R by a small molecule agonist
Dear Editor,
The glucagon-like peptide-1 receptor(GLP-1R)belongs to class B G protein-coupled receptors(GPCRs).It is a clinically proven target for type 2 diabetes and obesity.1 Several peptidic drugs have been approved including one in pill form,the oral semaglutide.Despite these advances,oral non-peptidic medicines have been pursued across the pharmaceutical industry for improved patient compliance with reduced side effects such as nausea and vomiting.1 The discovery of non-peptidic drugs has been hampered for many years,primarily owing to the difficulty of mimicking the peptide-receptor interactions with small molecule non-peptidic agonists.
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2021-01-29（万方平台首次上网日期，不代表论文的发表时间）
共3页
1140-1142
