Keeping innate immune response in check:when cGAS meets the nucleosome
Cao et al.report on cryo-EM structures of human cyclic GMP-AMP synthase(cGAS)sensor bound to the nucleosome core particle,thereby defining the molecular mechanism of how cGAS avoids activation by chromatinized self-DNA,Notably,disruption of cGAS dimer formation and prevention of dsDNA recognition by the sensor at the nucleosome level impede cGAS activation.
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2021-01-29(万方平台首次上网日期,不代表论文的发表时间)
共2页
1055-1056