25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor
Dear Editor,As of July, 2020, the ongoing pandemic of coronavirus diseases 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously 2019-nCoV) has caused more than 10.3 million human infections, with more than 506,000 deaths worldwide according to the World Health Organization.The clinical manifestations of COVID-19 vary from no asymptomatic infection, mild ”flu-like” symptoms, to lethal acute respiratory distress syndrome.The case mortality and fatality rates in people infected with SARS-CoV-2 increase steeply with age, and fatal outcomes are almost exclusively seen in people older than 50 years.1 Although the Food and Drug Administration has authorized emergency use of remdesivir for COVID-19 treatment in the US, the need for safe and effective antiviral drugs against SARS-CoV-2 remains urgent and unmet.
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We thank Drs;Youchun Wang and Weijin Huang for providing the SARS-CoV-2 pseudovirus system;We thank Dr;Saba Roghiyh Aliyari,Yanan Wang,Na-Na Zhang,Rong-Rong Zhang,Tian-Shu Cao and Yan Guo for critical reagents and helpful discussion;This project is supported by the Chinese Academy of Medical Sciences Initiative for Innovative Medicine ;Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences ;the National Natural Science Foundation of China ;NIH R01AI069120,AI158154 and AI140718 grants,University of California Los Angeles
2020-12-07（万方平台首次上网日期，不代表论文的发表时间）
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1043-1045
