CAR T cells: from tinkering to rational design
Hartl et al.and Wu et al.revealed that the CD3e subunit of the TCR-CD3 complex — a central player ofT cell activation — contains previously unrecognized signaling motifs that permit its functional coupling to tyrosine protein kinases.When grafted into chimeric antigen receptors (CARs), such signaling motifs enhance the antitumor activity of CAR T cells, a promising class of anti-tumoral therapeutics.T cells are central participants in adaptive immunity.They express T cell antigen receptors (TCRs) on their surface, through which they detect antigens in a highly sensitive manner.When the TCR binds to an antigen, the immunoreceptor tyrosine-based activation motifs (ITAMs) found in the TCR-associated CD3 chains are phosphorylated by the protein tyrosine kinase (PTK) Lck.This allows the recruitment and activation of the cytosolic PTK ZAP70 that phosphorylates the transmembrane adapter LAT, leading to the assembly of a multiprotein complex that ensures propagation and diversification of TCR signals.
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2020-12-07（万方平台首次上网日期，不代表论文的发表时间）
共2页
948-949
