Combating pancreatic cancer during its Rip Van Winkle sleep
In a recent paper published in Cell, Ruscetti et al.showed that therapy-induced senescence in pancreatic ductal adenocarcinoma (PDAC) rewires vascular network within the cancer,which in turn makes tumor susceptible to chemotherapy.Moreover, senescence-associated secretory phenotype-dependent activation of cancer vasculature increases T cell invasion into PDAC structures, thereby allowing better outcome of immunotherapy.
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2020-09-11(万方平台首次上网日期,不代表论文的发表时间)
共2页
637-638