Fibroblasts fuel intestinal tumorigenesis
Intestinal stromal cells play key roles in the regulation of intestinal stem cell biology, injury-induced intestinal epithelial regeneration, and tumorigenesis.Roulis and colleagues present evidence indicating that PGE2 secreted from PTGS2-expressing fibroblasts induces expansion of Sca-1+ reserve stem-like cells and accelerates intestinal adenoma formation via an EP4-YAP1 pathway.
30
2020-09-11(万方平台首次上网日期,不代表论文的发表时间)
共2页
635-636