Reprogramming the microenvironment: tricks of tumor-derived astrocytes
Medulloblastomas generate a complex ecosystem through the simultaneous evolution of tumor progenitor cells and transdifferentiated progeny (tumor-derived astrocytes).In a recent Cell paper, Yao et al.show that tumor-derived astrocytes secrete interleukin-4 to reprogram the innate immune system by polarizing resident brain microglia towards protumorigenic tumor-associated macrophages that secrete insulin-like growth factor 1, feeding back to stimulate tumor progenitor proliferation.
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2020-09-11(万方平台首次上网日期,不代表论文的发表时间)
共2页
633-634