GABAB receptor pas de deux: insights from high-resolution structures
The GABAB receptors are heterodimeric class C G proteincoupled receptors (GPCRs) that mediate the inhibitory neurotransmission in the central nervous system and they are drug targets for alcoholism and pain control.In a recent paper published in Cell Research, Mao et al.reported the first full-length GABAB heterodimer structures in both inactive and active states, providing a framework for understanding the activation of class C GPCRs and a template for designing allosteric modulators targeting the dimeric interface of the GABAB receptors.
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2020-09-11(万方平台首次上网日期,不代表论文的发表时间)
共2页
631-632