Cryo-EM structure of human bile salts exporter ABCB 11
Dear Editor,
Bile is a complex aqueous secretion produced by the liver that facilitates the digestion of lipids in the small intestine.A group of ATP binding cassette (ABC) transporters localizing at the apical canalicular domain of hepatocytes are responsible for the secretion of the bile organic solutes to the bile canaliculi,1 including organic anions, cholesterol, bile salts, glutathione,organic cations and phospholipid (Fig.1a).To date, the 3-D structures of ABCG2, ABCGS/G8, ABCB1, ABCB4 have been reported,2,3 leaving the structures of ABCB11 and ABCC2 unknown, despite we can get some information from the homologous structures of ABCC1,4 ABCB1 and ABCB4.
30
2020-08-14(万方平台首次上网日期,不代表论文的发表时间)
共3页
623-625