Ubiquitilated Fanconi ID complex embraces DNA
Mono-ubiquitination of the Fanconi ID complex is essential for inter-strand DNA repair and thereby prevents Fanconi anemia, a genetic disorder with high cancer risk.Using cryo-EM, Wang et al.and Alcon et al.compared mono-ubiquitinated and non-ubiquitinated ID compelexes and found that upon mono-ubiquitination, the ID complex undergoes conformational changes to form a ring encircling DNA.
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2020-08-14(万方平台首次上网日期,不代表论文的发表时间)
共2页
554-555