Structural basis for gating mechanism of Pannexin 1 channel
Dear Editor,
Pannexin 1 (PANX1) plays extensive physiological roles across diverse fields of biology, including cell death,1,2 inflammation,3 cancer progression,4 and neurological disorders,5 As suggested by biochemical analysis, PANX1 forms an oligomeric channel for the facilitated diffusion of ions and large molecules across the plasma membrane upon activation.6 However, the underlying molecular gating mechanism of PANX1 and the structure of human PANX1 are still elusive.In the current study, we report the cryo-EM structures of full-length and carboxyl-terminal (CT) tail-cleaved human PANX1.Combined with single-channel electrophysiological study, we identified the key residues involved in the gating of PANX1.
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2020-06-28(万方平台首次上网日期,不代表论文的发表时间)
共3页
452-454