Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1
Dear Editor,
DNA N6-methyladenine (6mA) modification is common in prokaryotes1 and eukaryotes,2 involving in gene regulation,transposon,stem cell differentiation,and human tumors.At present,it has been confirmed that 6mA is ubiquitous in the human genome,and [G/C]AGG[C/T] is the most prominent motif for 6mA modification.3 Human ALKBH1 (hALKBH1),one of the nine human homologs of the AIkB family,is an Fe(Ⅱ) and α-ketoglutarate (α-KG)-dependent dioxygenase and highly conserved in mammals.AIkB family proteins can repair damaged DNA/RNA or other lesions.hALKBH1 exhibits demethylation activity toward 6mA,and its abnormal expression has been found in many human cancers and developmental defects,such as tissue malformation and gender imbalance.3-s DNA methyltransferase N6AMT1 and demethylase hALKBH1 mediate the methylation and demethylation of DNA 6mA in the human genome,respectively.
30
2020-06-15（万方平台首次上网日期，不代表论文的发表时间）
共4页
272-275
