A new checkpoint against ferroptosis
By taking different approaches,two research groups made the same discovery that a CoQ oxidoreductase (renamed as ferroptosis suppressor protein-1,or FSP1) can inhibit ferroptosis,a form of cell death driven by iron-dependent phospholipid peroxidation.As FSP1 is expressed in various cancers and can halt ferroptosis even in the absence of glutathione peroxidase 4(GPX4),which was previously considered indispensable for ferroptosis surveillance,the potential of FSP1 as a new cancer therapeutic target should be explored.
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2020-04-27(万方平台首次上网日期,不代表论文的发表时间)
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