BAX and BAK become killers without a BH3 trigger

摘要：

It is widely believed that triggering mitochondria-dependent apoptosis requires that certain pro-apoptotic BH3-only proteins (e.g.,BID,BIM,etc.) of the BCL-2 family directly engage and activate the family”s essential effector proteins BAX and BAK,whose oligomerization then permeabilizes the mitochondrial outer membrane (MOM),committing the cell to apoptosis.However,by reconstituting a cell line engineered to lack all eight of the accepted BH3-only proteins,Huang et al.obtained evidence that these apoptotic triggers primarily target the anti-apoptotic BCL-2 relatives BCL-XL and MCL-1,concomitant neutralization of which enabled membrane-mediated spontaneous activation of BAX/BAK.

机标关键词：outer membrane、cell line

所属期刊栏目：29

分类号：R3 ;S

在线出版日期：2020-01-13（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：967-968