Nociceptor nerves set the stage for skin immunity
Nociceptor sensory neurons densely innervate the skin and detect potentially damaging stimuli.Cohen and colleagues show that nociceptor neurons drive local axonal reflexes that build anticipatory type 17 skin immune responses to protect the host against pathogens.The skin is a barrier tissue whose loss of integrity must be promptly recognized and defended to prevent pathogen invasion.Pain is an unpleasant sensation that accompanies skin injury and is mediated by nociceptor somatosensory neurons.Nociceptors are specialized to detect damage-associated stimuli including mechanical injury,noxious heat,cold,and reactive chemicals.1 Nociceptors also have the ability to directly detect pathogens including Candida albicans,2,3 Streptococcus pyogenes,4 and Staphylococcus aureus.5 Nociceptors densely innervate the skin and have a characteristic wide coverage due to ramifications of their peripheral nerve branches.To produce adaptive responses,nociceptors initiate neural reflexes that integrate the activity of the receptor cell (in this case,a nociceptor neuron) to an effector cell to generate responses that protect from danger,which include pain-induced motor withdrawal and sympathetic reflexes.
Staphylococcus aureus、peripheral nerve、immune responses、Candida albicans、sensory neurons
29
R76;R5
2019-12-31（万方平台首次上网日期，不代表论文的发表时间）
共2页
877-878
