Halting triple negative breast cancer by targeting PROCR
Cancer stem cells (CSCs) achieved prominence as a concept to explain the inexorable growth of cancers,but the paucity of robust CSC markers for solid tumors has seen the field wane in recent years.Wang et al.now report that a cell surface protein PROCR (Protein C Receptor) enriches for CSCs in about half of triple negative breast cancers and show that inhibition of receptor function by a nanobody profoundly decreases tumor growth,thus highlighting PROCR as a potential therapeutic target.
cell surface protein、tumor growth、stem cells
29
R73;O29
2019-12-31(万方平台首次上网日期,不代表论文的发表时间)
共2页
875-876