Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders
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Dear Editor,Autism spectrum disorders (ASD) are complex neurodevelopmental disorders characteristic of core behavioral traits like restricted,repetitive behaviors and deficiency in social interactions.1 The prevalence of ASD has rapidly increased worldwide,rising from 1/149 in 2000,1/68 in 2012,and to ～1/40 in 2016 of children at the age of 3-17 in the United States.2 ASD prevalence was found to be associated with socioeconomic status (SES) as overpresented in high-income households,3 and to be significantly enriched in certain regions,e.g.,reaching up to 4.88％ in Florida.2 In the last decades,advances in genetic studies have led to unprecedented understanding of the genetic factors that were associated with ＜ 50％ of human ASD.Tens of thousands of genomic events or gene mutations were found in ASD patients.Among these genetic factors,many seemed to indeed play causal roles in ASD etiology as animals bearing some of ASD-associated mutations manifested autistic-like behaviors.4-7 Since genetic factors are usually SES independent and unlikely to change in every few years,non-genetic factors including changes in life styles,environmental factors and their complex interaction with genetic factors are believed to prominently contribute to the recent rapidly increasing ASD prevalence.4-6 However,their nature and mechanisms of action remain largely undetermined.
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We thank Ms Mei Lu,Dr Yalan Wu and all other members of the laboratory for their support.We acknowledge the support from the Core Facility for Molecular Biology and the Core Facility for Cell Biology in SIBCB.We thank Ms Myung Eun Oh for help with manuscript preparation.This work was funded by the SXDB19040102,XDA12040323;the Key Scientific and Technological Projects of Guangdong Province2018B030335001;the National Natural Science Foundation of China81525019,81771223,91853128 and 81601203;the National Science and Technology Major Project2018ZX10101004;the National Key R&D program of China2018YFA0508200;the Guangzhou Science innovation and Development program201803010092;R.H.was also supported by funding from State Key Laboratory of Dairy Techniques in Guangming Dairy Inc.and the CAS Instrument Developing ProjectYZ201339
