De-fusing mitochondria defuses the mtDNA time-bomb
Being uniparentally inherited and with a high mutation rate,mitochondrial DNA (mtDNA) should relentlessly acquire mutations,eventually destroying a species through ”mutational meltdown”.Lieber et al.now show that mitochondrial fragmentation is an essential first step in Drosophila,preventing functional complementation by wild-type molecules,and packaging mutations into mitochondria before they are destroyed by mitophagy.
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2019-12-11(万方平台首次上网日期,不代表论文的发表时间)
共2页
781-782