Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression
Dear Editor,FOXA1,a forkhead (FKHD) family transcription factor,is highly expressed in the epithelium of endoderm-derived organs,including the prostate gland.1 Transgenic mouse studies have shown that FOXA1 expression is required for prostate epithelial cell differentiation and ductal morphogenesis during development and for the maintenance of this differentiated epithelial phenotype in the adult.Mechanistically,FOXA1 binds FKHD motifs in the DNA to open chromatin and increase local accessibility,thereby recruitingandrogen receptor (AR) to prostate lineagespecific enhancers.
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We thank Dr Daniel Foltz Northwestern University for helpful discussions.This work was supported in part by the NIH R50CA211271;NIH prostate SPORE P50CA180995;Prostate Cancer Foundation 2017CHAL2008
2019-11-04（万方平台首次上网日期，不代表论文的发表时间）
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773-775
