Crystallizing BubRl”s kinase activity
BubR1 has been implicated in fundamental biological processes such as cell division,cancer,aging and age-related diseases,but whether this mitotic checkpoint protein acts as a kinase has remained a matter of intense debate.With a multipronged approach involving the use of structural biology,substrate identification,pharmacological inhibition of kinase activity,and functional assays,Huang et al.now provide compelling evidence that BubR1 has enzymatic activity.
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2019-09-09(万方平台首次上网日期,不代表论文的发表时间)
共2页
605-606