Canine transmissible venereal tumor genome reveals ancient introgression from coyotes to pre-contact dogs in North America
Dear Editor,Canine transmissible venereal tumor (CTVT),the oldest known somatic cell line,is a living fossil of the original founder,transmitted from host”s cancer cells to other canids during the mating process.1 Since it was shown ten years ago that living cells from an ancient host could be transmitted among canids,the origin of CTVT has been studied continuously2.Recent comparison of the CTVT genetic data with a more comprehensive canine reference panel including pre-contact dogs (PCDs) from North America argued that the CTVT founder (the original canid infected with CTVT) is the closest detectable lineage to PCDs,and that this clade underwent introgression from wild canids in North America.3
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We thank Krishna R.Veeramah and Yong Zhou BGI,Shenzhen,China for providing valuable suggestions,Qi-Jun Zhou for collecting CTVT samples and laboratory work,Newton O.Otecko for providing dog samples from Kenya,Ming-Shan Wang for collecting dog samples from Sri Lanka,Shi-Fang Wu for collecting other31621062,91731304,41672021 and 41630102;the Animal Branch of the Germplasm Bank of Wild Species,CAS the Large Research Infrastructure Funding.Q.F.is supported by CASXDA19050102,QYZDB-SSW-DQC003,and XDPB05;the Howard Hughes Medical Institute 55008731.G.-D.W.is supported by the Youth Innovation Promotion Association,CAS
2019-08-06（万方平台首次上网日期，不代表论文的发表时间）
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592-595
