The insulin receptor goes nuclear
Regulation of gene expression is a major component of insulin action,which is classically thought to occur via phosphorylation,relocalization and/or processing of transcriptional regulators downstream of the insulin receptor (IR) signaling cascade.A recent study in Cell suggests a mechanism by which IR itself translocates to the nucleus and forms transcriptional complexes with RNA polymerase Ⅱ,host cell factor-1 and transcription factors to directly regulate gene expression,thus adding a new complementary pathway to control this important set of insulin actions.
29
2019-08-06(万方平台首次上网日期,不代表论文的发表时间)
共3页
509-511