Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis

摘要：

Dear Editor,Cancer cells often upregulate the expression of ligands for the inhibitory immune checkpoints receptor to escape anti-tumor immunity1.Targeting inhibitory immune checkpoints has become one of the most promising anticancer therapeutic inventions.Infiltration of myeloid cells,especially phagocytic cells,to tumors is often associated with chemotherapy resistance and progression of various cancer types.Phagocytosis of cancer cells is the major mechanism for these myeloid cells-mediated antitumor activity.However,many types of cancer cells express high level of”don”t eat me”signals on the cell surface to escape the phagocytic cells-mediated antitumor immunity.

所属期刊栏目：29

资助基金：We thank Dr.Weirui Ma and Yufeng Shi for kindly providing CD47 plasmids,Yingcong Wang and Prof.Jumei Shi for providing cell lines.We also thank the members of the Wang lab for their assistance.This work was supported by the National Natural Science Foundation of China81625019,31830053,31871398,31801177,31S00735,31801178,31800757;the Science Technology Commission of Shanghai Municipality16JC1404500,18410722000;the Commission of Health and Family Planning of Shanghai Municipality2017BR014 to P.W.,2017YQ068 to L.F.;the Young Elite Scientist Sponsorship Program by CASTYESS2018QNRC001;the Shanghai Sailing Program18YF1419500,18YF1419300;the Fundamental Research Funds For the Central Universities22120170259,22120180043,22120180045,22120180049

在线出版日期：2019-07-29（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：502-505