How cancers usurp macrophages to keep growing
Liu et al.report the direct interaction of tumor-associated macrophages with cancer stem cells (CSC) through specific ligand-receptor binding (LSECtin-BTN3A3),and how targeting this receptor-ligand interaction decimates the CSC pool.Cancer stem cells (CSC)1 have long been viewed as something akin to primordial matter:at times self-starters able to generate an entire tumor when only a few hundred of them are injected,and at other times sleepers that can weather the attack of a chemotherapy treatment only to raise their ugly heads years later.
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2019-07-29(万方平台首次上网日期,不代表论文的发表时间)
共2页
423-424