Anti-Zika virus RNAi in neural progenitor cells
Zika virus (ZIKV),a flavivirus that is primarily transmitted by mosquitoes,can cause devastating microcephaly and other congenital syndromes in infants born to infected pregnant women.In a recent paper in Cell Research,Xu et al.present data demonstrating that (i) ZlKV infection induces RNA interference (RNAi)-mediated antiviral defense in human neural progenitor cells and (ii) treatment with enoxacin,a broad-spectrum antibiotic with known RNAi-enhancing activity,prevents ZIKV infection and microcephalic defect in brain organoids.
29
2019-05-21(万方平台首次上网日期,不代表论文的发表时间)
共2页
261-262