STIM1 is a precise thermo-sensor in skin

摘要：

The Ca2+ sensor,STIM1,couples to activate Orai Ca2+ channels in response to endoplasmic reticulum Ca2+ depletion.New in vivo targeting approaches reveal that STIM1 mediates precise temperature sensing in skin through heatinduced regulation of Orai channels.Cells utilize Ca2+ as a universal second messenger to activate and coordinate a wide spectrum of cellular functions.The Orai family of plasma membrane (PM) channels mediate store-operated Ca2+ entry (SOCE) that is crucial in regulating transcription,secretion,motility,and growth.

所属期刊栏目：29

在线出版日期：2019-05-21（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：259-260