Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome
Dear Editor,Microbiome affects many aspects of human health and disease and elicits a wide range of host responses including remarkable epigenetic changes such as DNA methylation,histone modification and non-coding RNA expression.1 A still poorly explored area of microbiome-host interaction is the response of host RNA modification.N6-methyladenosine (m6A) is the most abundant mRNA modification in mammalian cells,occurring at ～3 modified adenosine residues per transcript.The m6A mapping and biology have been extensively studied recently.2 At the physiological level,m6A affects embryonic development,circadian clock,immunoresponse,and others.At the cellular and molecular level,m6A affects all key aspects of mRNA processing,translation and decay.Importantly,m6A is a predominant,transcriptome-wide mark that is responsive to environmental changes;this dynamic m6A pattern is maintained by the writer enzyme complex containing the METTL3 and METTL14 proteins,and two eraser enzymes of FTO and ALKBH5.
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We thank Dr.Hilary Morrison for assistance in 16S rRNA gene sequencing.We are grateful to Drs.Katya Frazier and Vanessa Leone from Dr.Eugene B.Chang”s laboratory for providing mouse tissues and insightful discussion.This work was supported by National Institutes of HealthK01 DK111764 to XYW,RM1 HG008935 to TP;DoD/CDMRPBC160450 to TP;the National Natural Science Foundation of China31741033 and 91753129 to GZL
2019-03-26（万方平台首次上网日期，不代表论文的发表时间）
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