Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade
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We thank Yigong Shi for advice and assistance.We thank the staff at the beamline 8L17U1 of the Shanghai Synchrotron Radiation Facility for their assistance.We also thank Lan Huang for the tagged proteasome cell line.This work was supported by funding from the National Key Research and Development Pr2017YFD0500400 to Z.M.,2016YFC0906000 to F.W.,and 2017YFA0505200 to W.H.;the Ministry of Science and Technology of China2015CB910104 to J.W.;the National Natural Science Foundation of China31640016,31870791,91753205 to Z.M.,21625104 to W.H.,and 31140022,21736002 and 31770827 to F.W.;the Beijing Institute of Technology Research Fund Program for Young Scholars to F.W.,the Research Fund for the Doctoral Program of Higher Education of China 20110002120058 to F.W.,the Fundamental Research Funds for the Central Nonprofit Scientific Institution Y2016JC25 to Z.M.and the Agricultural Sc
2019-01-12(万方平台首次上网日期,不代表论文的发表时间)
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1186-1194