A new STAT3 function: pH regulation
In a recent paper published in Cell Research,Liu et al.describe a novel function of STAT3,a classical oncogene,on lysosomes to regulate pH by interacting with the vacuolar H+-ATPase.This finding suggests a new anti-cancer strategy by limiting this function.Each of the seven members of the Signal Transducer and Activator of Transcription (STAT) family of transcription factors is phosphorylated on a single conserved tyrosine residue in response to a wide variety of cytokines,including the interferons and cytokines that activate the common gp130 receptor.1 However,STAT3 is the only family member whose expression is required for normal development.Moreover,in many different tumors,STAT3 is an oncogene whose activation through tyrosine phosphorylation is maintained indefinitely,in contrast to the rapid downregulation of STAT3 phosphorylation in normal tissues that have been exposed to pro-inflammatory signals.
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2018-12-20（万方平台首次上网日期，不代表论文的发表时间）
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