Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration
Dear Editor,Hematopoietic stem cells (HSCs) have unique self-renewal capacity to replenish the entire blood system,which is essential for various stress conditions,such as serial transplantation,ionizing radiation,anti-cancer medication,hemorrhage or infection.1 N6-methyl-adenosine (m6A),the most prevalent reversible nucleotide modification in cellular mRNA in eukaryotes,2 is associated with the maturation,translation,and eventual decay of protein-coding transcripts.
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the National Key R&D Program of China2017YFA0103302,2016YFA0100602,2018YFA0109300;the National Natural Science Foundation of China 91749203,91749117,81525010,81420108017 and 81770155.This work was also supported by the National Science Fund for Excellent Young Scholars31622039;the Science Foundation for Distinguished Young Scholars of Jiangsu ProvinceBK20160045
2018-11-22（万方平台首次上网日期，不代表论文的发表时间）
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1035-1038
