Cyclic GMP-AMP synthase (cGAS) is activated by DNA through direct binding.Active cGAS catalyzes the production of cyclic GMP-AMP (cGAMP),and consequently activates the innate immune responses.However,the detailed biological processes are poorly understood.Du and Chen demonstrated in a recent paper published on Science that DNA binding to cGAS robustly induced the formation of liquid like droplets in which cGAS was activated.
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the National Natural Science Committee of China91753141 to Hua-Bing Li;the Program for Professor of Special Appointment Eastern Scholar at Shanghai Institutions of Higher Learning;the start-up fund from the Shanghai Jiao Tong University School of Medicine;the Howard Hughes Medical Institute