Staged profiling of sperm development in sync
By synchronizing the first wave of spermatogenesis,Chen and colleagues profile gene levels and regulation dynamics in 20 stages of sperm development.From this,newfound molecular signatures of sperm maturation are unearthed and validated.In humans,250 million sperm are made daily,taking ~74 days to reach maturation involving a sequential process of differentiation,mitotic proliferation and meiosis,culminating in spermiogenesis.1 Sperm development in the mouse,while taking half the time,is no less complex.Understanding how this protracted process of spermatogenesis proceeds is of great interest,considering that defects in this process lead to infertility.In a recent paper in Cell Research,Chen et al.describe their strategy to meticulously purify and profile the development of sperm,crucially using a synchronized mouse model.2This analysis has not only allowed for the characterization of gene dynamics during maturation,but has also led to the discovery and validation of previously uncharacterized stage-specific regulators and surface markers.
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2018-11-22(万方平台首次上网日期,不代表论文的发表时间)
共2页
965-966