Guiding a mutator in antibody diversification
Activation Induced Cytidine Deaminase is a mutator that is essential for antibody diversification.A new study,recently reported in Cell Research,provides insights into the mechanism that guides the mutator to physiological targets.The immune system produces diverse antibodies to counter infections.Three mechanisms contribute to antibody diversity (Fig.1).1 During B cell maturation,V(D)J recombination creates a large repertoire of antigen-binding sites in immunoglobulin (Ig) variable regions.Na(i)ve B cells express the primary antigen-binding sites in the context of B cell receptors.Antigenic challenge triggers B cell activation.In this process,class switch recombination (CSR) changes the constant region of Ig heavy chain (IgH),which defines antibody class.All na(i)ve B cells express IgM and IgD,whereas activated B cells express IgG,IgA or IgE.As different classes of antibody are specialized for distinct immune functions,class switching broadens the scope of immune response.In parallel with CSR,somatic hypermutation (SHM) modifies antibody variable regions to improve antigen-binding affinity.
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2018-11-22（万方平台首次上网日期，不代表论文的发表时间）
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963-964
