m6A RNA modification controls autophagy through upregulating ULK1 protein abundance
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Dear Editor,N6-methyladenosine (m6A) is the prominent dynamic mRNA modification,governed by methyltransferase complex (”writers”),demethylases (”erasers”) and RNA-binding proteins (”readers”).1 m6A modification directs mRNAs to distinct fates by grouping them for differential processing,translation and decay in the processes such as cell differentiation,embryonic development and stress responses.1,2 Owing to a deeper understanding of this modification and the technological advance,functional characterizations of m6A in gene regulation have become a hot topic that warrants further dissection.3,4
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the National Natural Science Foundation of China31700760,31522018,91629101,91753137,31771462,31471252,31500813;the National Key Basic Research Program of China2015CB859800,2014CB910800;Science and Technology Planning Project of Guangzhou,China201804010385,201604020003,201604046001;China Postdoctoral Science Foundation2017M622862