Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis
Dear Editor,Foci of cell death are commonly observed in core regions of solid tumors as a result of inadequate vascularization and subsequent metabolic stresses such as hypoxia and glucose deprivation. Since the morphology of dead tumor cells appears to be necrotic, it is often referred as tumor necrosis. Tumor necrosis has been found to be associated with tumorigenesis and poor prognosis for years,1 but the role of necrosis in tumor development is still largely unknown. Additionally, the molecular mechanism of necrosis is an under-studied area due to the lack of experimental system for manipulating necrotic cell death. Necroptosis is a form of programmed, caspase-independent necrosis.2 Studies on TNF-induced necroptosis have improved our understanding on the molecular mechanism of necroptosis. It is now known that the protein kinases receptor interacting protein kinase 1 (RIPK1), RIPK3 and the mixed lineage kinase domain-like(MLKL) constitute the core of the necroptosis machinery.3-5
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We thank Dr. Glenn Merlino for his critical suggestions on this project. This research was supported by the Intramural Research Program of the Center for Cancer Research, National Cancer Institute, National Institutes of Health. We gratefully acknowledge the assistance of Alex Alfortish and Celeste Faia, and the Louisiana Cancer Research Consortium LCRC Biospecimen Core Laboratory for provision of the tissue samples.
2018-10-10（万方平台首次上网日期，不代表论文的发表时间）
共3页
868-870
